The use analysis of variance
methods at clinical research
phase 1-st of the «Altabor»
V. E. Dobrova, M. G. Starchenko, T. V. Saienko
Abstract
In work the analysis of variance method
used for estimation of three doses tolerability
of the «Altabor» is presented.
Comparison of parameters of general and
biochemical blood tests, indexes of koagulogramm
for three groups is conducted. It
was shown, that the increase of single dose
did not affect the indexes of general blood
test. Statistically meaningful differences
were observed for the two from ten parameters
of biochemical blood test and three
from four parameters of koagulogramm.
The use of analysis of variance at research
of the «Altabor» allowed to expose the tendencies
of influencing of factor of increase
of dose, which were taken into account at
estimation of non-permanent dose tolerability
and in subsequent researches of
course dose tolerability
Keywords: clinical trials, tolerability, medicine
«Altabor», analysis of variance.